NEUROTROPHIN-4/5 PROTECTS HIPPOCAMPAL AND CORTICAL-NEURONS AGAINST ENERGY DEPRIVATION-INDUCED AND EXCITATORY AMINO ACID-INDUCED INJURY

被引：48
|
作者：
CHENG, B
GOODMAN, YD
BEGLEY, JG
MATTSON, MP
机构：
[1] UNIV KENTUCKY, SANDERS BROWN CTR AGING, LEXINGTON, KY 40536 USA
[2] UNIV KENTUCKY, DEPT ANAT & NEUROBIOL, LEXINGTON, KY 40536 USA
来源：
BRAIN RESEARCH | 1994年 / 650卷 / 02期
基金：
美国国家卫生研究院;
关键词：
ALAMAR BLUE; BRAIN-DERIVED NEUROTROPHIC FACTOR; CALCIUM; GLUCOSE DEPRIVATION; GLUTAMATE; NERVE GROWTH FACTOR;
D O I：
10.1016/0006-8993(94)91801-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neurotrophin-4/5 (NT-4/5) is a recently discovered member of the neurotrophin family of neurotrophic factors which includes NGF, BDNF and NT-3. NT-4/5 is expressed in the brain where its function is unknown. We have found that NT-4/5 can protect cultured embryonic rat hippocampal and cortical neurons against glucose deprivation-induced injury. Significant protection was observed with NT-4/5 concentrations from 100-1000 ng/ml, with a dose-response curve similar to that of BDNF. Neuronal vulnerability to glutamate toxicity was significantly reduced in cultures pretreated with NT-4/5. Moreover, neurons pretreated with NT-4/5 were more resistant to toxicity induced by calcium ionophore A23187, demonstrating that NT-4/5 increases neuronal resistance to calcium-mediated injury. These data indicate that, as with other neurotrophins, NT-4/5 may serve a neuroprotective function in the brain.
引用
收藏
页码：331 / 335
页数：5
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