Efficient One-Pot Synthesis of Triazole-Linked Morpholinone Scaffolds by CuAAC in the Presence of 18-Crown-6

被引：2
作者：
Mayooufi, A. [1 ,2 ]
Romdhani-Younes, M. [2 ]
Thibonnet, J. [1 ]
机构：
[1] Univ Tours, Lab Synth & Isolement Mol BioAct SIMBA, EA7502, Fac Sci & Tech, Parc Grandmont,32 Ave Monge, F-37200 Tours, France
[2] Fac Sci Tunis, Lab Chim Organ Struct & Macromol, Dept Chim, Campus Univ El Manar,Rue Bechir Salem Belkheiria, Tunis 2092, Tunisia
来源：
SYNOPEN | 2018年 / 2卷 / 04期
关键词：
click chemistry; iodolactonization; morpholinones; azides; 1,2,3-triazole; one-pot procedure;
D O I：
10.1055/s-0037-1610399
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A range of bis-heterocyclic derivatives based on novel morpholinone and triazole heterocycles was prepared from iodo-morpholinone. The key step in our strategy is a one-pot procedure based upon copper-catalysed alkyne-azide cycloaddition (CuAAC) from iodo-morpholinone.
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收藏
页码：298 / 305
页数：8
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