THE GENERATION OF MOLECULAR DIVERSITY

被引：126
作者：
PAVIA, MR
SAWYER, TK
MOOS, WH
机构：
[1] WARNER LAMBERT PARKE DAVIS,PARKE DAVIS PHARMACEUT RES DIV,ANN ARBOR,MI 48105
[2] CHIRON CORP,EMERYVILLE,CA 94608
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 03期
关键词：
D O I：
10.1016/S0960-894X(01)80220-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
To define the chemical basis of ligand/ligate interactions it is often desirable to prepare and evaluate a large number of peptide analogues. The traditional serial process is being replaced by a variety of highly sophisticated methods in which large libraries of peptide ligands are synthesized in parallel and screened against ligates of interest. These techniques add tremendous power to the drug discovery process and herein we review the progress made in this arena.
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页码：387 / 396
页数：10
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