A PEPTIDE FROM SCHUMANNIOPHYTON-MAGNIFICUM WITH ANTI-COBRA VENOM ACTIVITY

被引：16
|
作者：
HOUGHTON, PJ [1 ]
OSIBOGUN, IM [1 ]
BANSAL, S [1 ]
机构：
[1] KINGS COLL LONDON, CHELSEA DEPT PHARM, PHARMACEUT CHEM RES LABS, LONDON SW3 6LX, ENGLAND
来源：
PLANTA MEDICA | 1992年 / 58卷 / 03期
关键词：
SCHUMANNIOPHYTON-MAGNIFICUM; RUBIACEAE; PEPTIDES; ANTI-SNAKE VENOM ACTIVITY;
D O I：
10.1055/s-2006-961449
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Using the chick biventer cervicis preparation as a bioassay for antivenom activity, a peptide has been isolated from the aqueous extract of the bark of Schumanniophyton magnificum. The peptide was isolated and purified by a combination of reverse-phase and exclusion column chromatography, preparative TLC, and HPLC. The peptide has a relative molecular mass of about 6000 daltons and is similar in amino acid composition to the cardiotoxins present in snake venom. The isolated peptide showed dose-related inhibitions of the effects of cardiotoxin and total venom of cobra species using the chick biventer cervicis preparation.
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收藏
页码：263 / 265
页数：3
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