MOUSE IL-3 INDUCES HISTAMINE-RELEASE FROM MOUSE PERITONEAL MAST-CELLS

被引:8
|
作者
TAKAISHI, T
MORITA, Y
HIRAI, K
YAMAGUCHI, M
YOKOTA, T
ARAI, K
ITO, K
MIYAMOTO, T
机构
[1] UNIV TOKYO,INST MED SCI,DEPT MOLEC & DEV BIOL,TOKYO 113,JAPAN
[2] NATL SAGAMIHARA HOSP & RES CTR RHEUMATOL ALLERGY,KANAGAWA,JAPAN
关键词
GM-CSF; HISTAMINE RELEASE; IL-1-ALPHA; IL-1-BETA; IL-3; IL-4; IL-5; IL-8; MOUSE PERITONEAL MAST CELLS; PHOSPHATIDYL SERINE;
D O I
10.1159/000236186
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
In this study, we have attempted to determine whether mouse peritoneal mast cells released histamine in response to IL-3. Recombinant mouse (m)IL-3 induced histamine release from mouse peritoneal mast cells in a dose-dependent fashion. Histamine release did not occur in the absence of phosphatidyl serine (PS), and was dependent on PS concentrations. The release was 14.3 +/- 3.8 and 43.5 +/- 11.5% (mean +/- SEM, n = 5) at 1 nM IL-3 in the presence of 10 and 20-mu-g/ml of PS. Calcium was required for the response, and in the absence of calcium, significant histamine release was not observed. The kinetics were slower than those of anti-IgE-induced response. IL-3-induced histamine release reached a peak within 15 min, while that by anti-IgE reached 80% of the maximum in 3 min. Lower concentrations of IL-3, which failed to directly induce histamine release, did not enhance anti-]gE-induced histamine release. Other cytokines, including mIL-4, mIL-5, m-granulocyte-macrophage colony-stimulating factor, human (h)IL-1-alpha, hIL-1-beta and hIL-8, neither induced histamine release nor enhanced anti-IgE induced histamine release. IL-4 had no capacity to enhance IL-3-induced histamine release. These results suggest that locally produced IL-3 might modulate mast cell-related inflammation through histamine release from mast cells.
引用
收藏
页码:205 / 210
页数:6
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