MUTABILITY BY POLYCYCLIC-HYDROCARBONS IS IMPROVED IN DERIVATIVES OF ESCHERICHIA-COLI WP2 UVRA WITH INCREASED PERMEABILITY

被引：7

作者：

HERRERA, G ^{[1
]}

URIOS, A ^{[1
]}

ALEIXANDRE, V ^{[1
]}

BLANCO, M ^{[1
]}

机构：

[1] FUNDAC VALENCIANA INVEST BIOMED,INST INVEST CITOL,AMADEO SABOYA 4,E-46010 VALENCIA,SPAIN

来源：

MUTATION RESEARCH | 1993年 / 301卷 / 01期

关键词：

CELL PERMEABILITY; PHAGE C21; ESCHERICHIA-COLI B;

D O I：

10.1016/0165-7992(93)90048-Z

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Escherichia coli B, unlike both E. coli K12 and Salmonella typhimurium, is sensitive to the rough-specific phage C21. This sensitivity is probably due to the incomplete lipopolysaccharide core of the E. coli B cells, which confers on them a partial permeability to large molecules. Derivatives of WP2 uvrA, a tryptophan-requiring E. coli B strain, were rendered still more permeable by selecting for C21-resistant clones. The new permeable strains, when tested for mutagenesis induced by polycyclic hydrocarbons, showed a mutagenic response higher than that of the parental strains.

引用

页码：1 / 5

页数：5

共 20 条

[1] IMPROVED BACTERIAL TEST SYSTEM FOR DETECTION AND CLASSIFICATION OF MUTAGENS AND CARCINOGENS [J].

AMES, BN ;

LEE, FD ;

DURSTON, WE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (03) :782-786

[2] AN EVALUATION OF THE ESCHERICHIA-COLI WP2 AND WP2 UVRA REVERSE MUTATION ASSAY [J].

BRUSICK, DJ ;

SIMMON, VF ;

ROSENKRANZ, HS ;

RAY, VA ;

STAFFORD, RS .

MUTATION RESEARCH, 1980, 76 (02) :169-190

[3] 2 MUTATIONS WHICH AFFECT THE BARRIER FUNCTION OF THE ESCHERICHIA-COLI K-12 OUTER-MEMBRANE [J].

COLEMAN, WG ;

LEIVE, L .

JOURNAL OF BACTERIOLOGY, 1979, 139 (03) :899-910

[4] SENSITIVITY OF DIFFERENT ESCHERICHIA-COLI AND SALMONELLA STRAINS IN MUTAGENICITY TESTING CALCULATED ON THE BASIS OF SELECTED LITERATURE [J].

DYRBY, T ;

INGVARDSEN, P .

MUTATION RESEARCH, 1983, 123 (01) :47-60

[5] MUTAGEN TESTING USING TRP+ REVERSION IN ESCHERICHIA-COLI [J].

GREEN, MHL ;

MURIEL, WJ .

MUTATION RESEARCH, 1976, 38 (01) :3-32

[6] LIPOPOLYSACCHARIDE-DEFICIENT, BACTERIOPHAGE-RESISTANT MUTANTS OF ESCHERICHIA-COLI K-12 [J].

HANCOCK, REW ;

REEVES, P .

JOURNAL OF BACTERIOLOGY, 1976, 127 (01) :98-108

[7] UV LIGHT-INDUCED MUTABILITY IN SALMONELLA STRAINS CONTAINING THE UMUDC OR THE MUCAB OPERON - EVIDENCE FOR A UMUC FUNCTION [J].

HERRERA, G ;

URIOS, A ;

ALEIXANDRE, V ;

BLANCO, M .

MUTATION RESEARCH, 1988, 198 (01) :9-13

[8] RECENT DEVELOPMENTS IN BACTERIAL SHORT-TERM TESTS FOR THE DETECTION OF GENOTOXIC AGENTS [J].

HOFNUNG, M ;

QUILLARDET, P .

MUTAGENESIS, 1986, 1 (05) :319-330

[9]

JANSSON PE, 1981, EUR J BIOCHEM, V115, P571

[10] REVISED METHODS FOR THE SALMONELLA MUTAGENICITY TEST [J].

MARON, DM ;

AMES, BN .

MUTATION RESEARCH, 1983, 113 (3-4) :173-215

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