ISOLATION AND CHARACTERIZATION OF NEW PEPTIDE ANTIBIOTICS, PLUSBACINS A1-SIMILAR-TO-A4 AND B1-SIMILAR-TO-B4

被引：41

作者：

SHOJI, J ^{[1
]}

HINOO, H ^{[1
]}

KATAYAMA, T ^{[1
]}

MATSUMOTO, K ^{[1
]}

TANIMOTO, T ^{[1
]}

HATTORI, T ^{[1
]}

HIGASHIYAMA, I ^{[1
]}

MIWA, H ^{[1
]}

MOTOKAWA, K ^{[1
]}

YOSHIDA, T ^{[1
]}

机构：

[1] SHIONOGI & CO LTD,SHIONOGI RES LAB,FUKUSHIMA KU,OSAKA 553,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 06期

关键词：

D O I：

10.7164/antibiotics.45.817

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New antibiotics, plusbacins A1 approximately A4 and B1 approximately B4, were isolated from the culture broth of a strain of Pseudomonas sp. These antibiotics were isolated as a complex by column chromatographies on Diaion HP-20 and silica gel, and then separated by HPLC. They are amphoteric in nature. The hydrochlorides are obtained as colorless powders, soluble in methanol and alkaline water. From their physico-chemical properties, these antibiotics are presumed to be acyloctapeptides containing a lactone linkage, and their differences occur in amino acid and fatty acid residues. The antibiotics are active against Gram-positive bacteria in vitro and in vivo.

引用

页码：817 / 823

页数：7

共 7 条

[1] THE STRUCTURES OF KATANOSIN-A AND KATANOSIN-B [J].

KATO, T ;

HINOO, H ;

TERUI, Y ;

KIKUCHI, JK ;

SHOJI, J .

JOURNAL OF ANTIBIOTICS, 1988, 41 (06) :719-725

[2] EMPEDOPEPTIN (BMY-28117), A NEW DEPSIPEPTIDE ANTIBIOTIC .1. PRODUCTION, ISOLATION AND PROPERTIES [J].

KONISHI, M ;

SUGAWARA, K ;

HANADA, M ;

TOMITA, K ;

TOMATSU, K ;

MIYAKI, T ;

KAWAGUCHI, H ;

BUCK, RE ;

MORE, C ;

ROSSOMANO, VZ .

JOURNAL OF ANTIBIOTICS, 1984, 37 (09) :949-957

[3] STUDIES ON BACTERIAL-CELL WALL INHIBITORS .6. SCREENING METHOD FOR THE SPECIFIC INHIBITORS OF PEPTIDOGLYCAN SYNTHESIS [J].

OMURA, S ;

TANAKA, H ;

OIWA, R ;

NAGAI, T ;

KOYAMA, Y ;

TAKAHASHI, Y .

JOURNAL OF ANTIBIOTICS, 1979, 32 (10) :978-984

[4]

Palleroni N.J., 1984, BERGEYS MANUAL SYSTE, P141, DOI DOI 10.1099/00207713-35-3-408

[5] STRUCTURES OF NEW PEPTIDE ANTIBIOTICS, PLUSBACINS A1-A4 AND B1-B4 [J].

SHOJI, J ;

HINOO, H ;

KATAYAMA, T ;

NAKAGAWA, Y ;

IKENISHI, Y ;

IWATANI, K ;

YOSHIDA, T .

JOURNAL OF ANTIBIOTICS, 1992, 45 (06) :824-831

[6] ISOLATION AND CHARACTERIZATION OF KATANOSIN-A AND KATANOSIN-B [J].

SHOJI, J ;

HINOO, H ;

MATSUMOTO, K ;

HATTORI, T ;

YOSHIDA, T ;

MATSUURA, S ;

KONDO, E .

JOURNAL OF ANTIBIOTICS, 1988, 41 (06) :713-718

[7] EMPEDOPEPTIN (BMY-28117), A NEW DEPSIPEPTIDE ANTIBIOTIC .2. STRUCTURE DETERMINATION [J].

SUGAWARA, K ;

NUMATA, K ;

KONISHI, M ;

KAWAGUCHI, H .

JOURNAL OF ANTIBIOTICS, 1984, 37 (09) :958-964

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