A NOVEL GC-RICH HUMAN MACROSATELLITE VNTR IN XQ24 IS DIFFERENTIALLY METHYLATED ON ACTIVE AND INACTIVE X-CHROMOSOMES

被引：72
作者：
GIACALONE, J
FRIEDES, J
FRANCKE, U
机构：
[1] STANFORD UNIV, MED CTR, SCH MED, DEPT GENET, STANFORD, CA 94305 USA
[2] STANFORD UNIV, MED CTR, SCH MED, HOWARD HUGHES MED INST, STANFORD, CA 94305 USA
[3] UNIV CALIF SAN FRANCISCO, DEPT OBSTET GYNECOL & REPROD SCI, SAN FRANCISCO, CA 94143 USA
来源：
NATURE GENETICS | 1992年 / 1卷 / 02期
关键词：
D O I：
10.1038/ng0592-137
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A new X chromosome-specific repetitive sequence, a 3 kilobase HindIII clone with a base composition of 63% C+G, has been isolated. The sequence is organized as a hypervariable tandem repeat cluster ranging in size from 150-350 kilobases, with outlying single copies. This locus, designated DXZ4 and mapped to chromosome band Xq24, may consist of as many as 50 variable-length alleles. It represents a class of variable number of tandem repeat polymorphism which may be termed 'macrosatellite'. The cluster is highly methylated on the active X chromosome and hypomethylated on the inactive X.
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页码：137 / 143
页数：7
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