POPULATION-GENETICS OF HUMAN GLYOXALASES

被引：20
作者：
THORNALLEY, PJ
机构：
[1] Department of Chemistry and Biological Chemistry, University of Essex, Wivenhoe Park, Colchester
来源：
HEREDITY | 1991年 / 67卷
基金：
英国惠康基金;
关键词：
DIABETES; DIABETIC COMPLICATIONS; GLYOXALASE;
D O I：
10.1038/hdy.1991.73
中图分类号：
Q14 [生态学（生物生态学）];
学科分类号：
071012 ; 0713 ;
摘要：
The gene for glyoxalase I (E.C. 4.4.1.5), Glo, has two alleles, Glo1 and Glo2, which are autosomally inherited in a co-dominant manner. Glo1 allele-frequency is highest in native Alaskan-Eskimo and Indian populations and decreases geographically south and east, to minimum levels in Aboriginal-Australian populations and native tribes in Papua New Guinea. There was no correlation between Glo1 frequency and incidence of insulin-dependent diabetes mellitus (IDDM). The frequencies of GLO phenotypes, Glo 1-1, Glo 1-2 and Glo 2-2, are disturbed in IDDM and there is a suggestion that IDDM patients with or without chronic, clinical complications have characteristic phenotype frequencies.
引用
收藏
页码：139 / 142
页数：4
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