ISLET TRANSPLANTATION RESTORES NORMAL SERUM AMYLASE LEVELS IN DIABETIC RATS

被引:4
作者
BARNEO, L
ESTEBAN, MM
GARCIAPRAVIA, C
DIAZ, F
MARIN, B
机构
[1] Department of Functional Biology-Physiology, University of Oviedo
关键词
Amylase; Diabetes; Exocrine pancreas; Islet transplantation;
D O I
10.1159/000129095
中图分类号
R61 [外科手术学];
学科分类号
摘要
Diabetes is associated with a diminution in exocrine pancreatic function. The goal of our study was to investigate whether the altered exocrine pancreatic function of streptozotocin-induced diabetic rats could be ameliorated by islet transplantation. Diabetic rats received either more than 1,000 syngeneic islets intraportally (islet transplantation group) or pancreatic, nonviable insular tissue (sham transplantation group). Plasma amylase and insulin levels in diabetic rats were significnatly lower than in normal rats. The exocrine pancreas of streptozotocin-induced diabetic rats showed alterations (decrease of zymogen granules, diminution of endoplasmic reticulum, clusters of ribosomes without organization) in the structure of acinar cells at the electron microscopic level. After islet transplantation, plasma glucose levels were restored to normal values, and those of amylase and insulin gradually increased to normal values. A positive correlation between plasma levels of amylase and insulin was found. Three months after islet transplantation, the islet-transplanted rats did not show morphologic alterations of the acinar cells which were still found in the sham-transplanted rats. It is concluded that alterations of exocrine pancreas in streptozotocin-induced diabetic rats are ameliorated by islet transplantation. © 1990 S. Karger AG, Basel.
引用
收藏
页码:143 / 150
页数:8
相关论文
共 50 条
  • [41] PREVENTION OF HYPERGLYCEMIA IMPROVES THE LONG-TERM RESULT OF ISLET TRANSPLANTATION IN STREPTOZOTOCIN-DIABETIC RATS
    ARRAJAB, A
    AHREN, B
    PANCREAS, 1992, 7 (04) : 435 - 442
  • [42] Acarbose treatment or islet transplantation increase FAD-glycerophosphate dehydrogenase content in islets of diabetic rats
    Fabregat, ME
    Fernández-Alvareza, J
    Franco, C
    Corominola, H
    Mast, E
    Malaisse, WJ
    Gomis, R
    MEDICAL SCIENCE RESEARCH, 1999, 27 (06): : 393 - 396
  • [43] Glycaemic control in diabetic rats treated with islet transplantation using plasma combined with hydroxypropylmethyl cellulose hydrogel
    Schaschkow, Anais
    Sigrist, Severine
    Mura, Carole
    Barthes, Julien
    Vrana, Nihal Engin
    Czuba, Elodie
    Lemaire, Florent
    Neidl, Romain
    Dissaux, Caroline
    Lejay, Anne
    Lavalle, Philippe
    Bruant-Rodier, Catherine
    Bouzakri, Karim
    Pinget, Michel
    Maillard, Elisa
    ACTA BIOMATERIALIA, 2020, 102 : 259 - 272
  • [44] Recovery of function and mass of endogenous β-cells in streptozotocin-induced diabetic rats treated with islet transplantation
    Hamamoto, Y
    Tsuura, Y
    Fujimoto, S
    Nagata, M
    Takeda, T
    Mukai, E
    Fujita, J
    Yamada, Y
    Seino, Y
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 287 (01) : 104 - 109
  • [46] Noradrenergic and cholinergic reinnervation of islet grafts in diabetic rats
    Houwing, H
    VanAsperen, RM
    VanderZee, EA
    VanSuylichem, PTR
    Oestreicher, AB
    Steffens, AB
    Strubbe, JH
    CELL TRANSPLANTATION, 1996, 5 (01) : 21 - 30
  • [47] ISLET TRANSPLANTATION IMPROVES GLUCOSE-OXIDATION AND MECHANICAL FUNCTION IN DIABETIC RAT HEARTS
    LOPASCHUK, GD
    LAKEY, JRT
    BARR, R
    WAMBOLT, R
    THOMSON, ABR
    CLANDININ, MT
    RAJOTTE, RV
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1993, 71 (12) : 896 - 903
  • [48] Anti-diabetic and neuroprotective effects of pancreatic islet transplantation into the central nervous system
    Lazard, Daniel
    Vardi, Pnina
    Bloch, Konstantin
    DIABETES-METABOLISM RESEARCH AND REVIEWS, 2016, 32 (01) : 11 - 20
  • [49] TRANSPLANTATION OF FREE AND MICROENCAPSULATED ISLETS IN RATS - EVIDENCE FOR THE REQUIREMENT OF AN INCREASED ISLET MASS FOR TRANSPLANTATION INTO THE PERITONEAL SITE
    SIEBERS, U
    HORCHER, A
    BRETZEL, RG
    KLOCK, G
    ZIMMERMANN, U
    FEDERLIN, K
    ZEKORN, T
    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 1993, 16 (02) : 96 - 99
  • [50] REGULATION OF PANCREATIC AMYLASE AND LIPASE GENE-EXPRESSION BY DIET AND INSULIN IN DIABETIC RATS
    TSAI, A
    COWAN, MR
    JOHNSON, DG
    BRANNON, PM
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1994, 267 (04): : G575 - G583