T-MAZE PERFORMANCE IN RATS FOLLOWING CHRONIC NEUROLEPTIC TREATMENT

被引：3
作者：
FERRE, S
PRAT, G
GUIX, T
GOMA-I-FREIXANET, M
JANE, F
CASAS, M
机构：
[1] Laboratori de Neuropsicofarmacologia Programa Sant Pau-CITRAN Fundacio d'Investigacio, la Santa Creu i Sant Pau Hospital de Sant Pau (Medical School, U.A.B.), Barcelona
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1990年 / 35卷 / 02期
关键词：
Chronic treatment; Food-reinforced behaviour; Haloperidol; Locomotor activity; rat;
D O I：
10.1016/0091-3057(90)90190-S
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The effects of chronic haloperidol treatment (0.5 mg/kg/day for 21 days) on maze learning in the rat were studied. There were no differences between haloperidol- and saline-treated groups in percentage of correct responses, but the latency to respond was longer and extinction was faster in the haloperidol-treated group. We speculated that differences between both groups were due to a decrease of appetitive motivation in haloperidol-treated animals, probably caused by a decreased of dopaminergic neurotransmission. © 1990.
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页码：481 / 484
页数：4
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