USE OF SOMATIC GENE-TRANSFER TO STUDY LIPOPROTEIN METABOLISM IN EXPERIMENTAL-ANIMALS IN-VIVO

被引：17
作者：
CHAN, L
机构：
[1] BAYLOR COLL MED, DEPT CELL BIOL, HOUSTON, TX 77030 USA
[2] BAYLOR COLL MED, DEPT MED, HOUSTON, TX 77030 USA
来源：
CURRENT OPINION IN LIPIDOLOGY | 1995年 / 6卷 / 05期
关键词：
D O I：
10.1097/00041433-199510000-00014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Genetic manipulations of experimental animals have provided valuable information on lipoprotein metabolism in vivo. Somatic gene transfer is a novel method for introducing foreign genes into animals in vivo. Adenovirus-mediated transfer of genes for the LDL receptor, the receptor-associated protein, apolipoprotein A-I, apolipoprotein E, cholesterol 7 alpha-hydroxylase, and apolipoprotein B messenger RNA editing protein has resulted in high-level expression of these transgenes in mice and hamsters, and the production of interesting animal models of lipoprotein metabolism. Somatic gene transfer is a valuable tool for analyzing the role of transgenes in lipoprotein metabolism in vivo and for exploring the potential use of specific transgenes for human gene therapy.
引用
收藏
页码：335 / 340
页数：6
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