RELEASE OF CARTILAGE PROTEOGLYCAN DEGRADING ENZYME-ACTIVITY BY THIOGLYCOLLATE STIMULATED MOUSE PERITONEAL-MACROPHAGES IN CULTURE

被引：8
作者：
ACKERMAN, N
JUBB, S
TRIMBLE, B
YOXALL, B
机构：
[1] Syntex Research, Institute of Biological Sciences, Palo Alto, 94304, CA
来源：
AGENTS AND ACTIONS | 1979年 / 9卷 / 5-6期
关键词：
D O I：
10.1007/BF01968117
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Media from cultured mouse peritoneal macrophages were tested for cartilage proteoglycan degrading activity using S35-labelled rabbit ear cartilage. Media samples collected at 2-day intervals contained increasing amounts of activity between days two and six. This activity was activated by trypsin and antagonized by chelating agents. The macrophage products induced release of the proteoglycan component of cartilage as determined by biochemical and histological methods without affecting the collagen component. Media from cells incubated with hydrocortisone were devoid of proteoglycan degrading activity. © 1979 Birkhäuser Verlag.
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页码：488 / 496
页数：9
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