EFFECT OF PROSTAGLANDIN E1 ON FOREARM BLOOD FLOW

被引：55

作者：

BEVEGARD, S

ORO, L

机构：

[1] Departments of Internal Medicine and Clinical Physiology, Thoracic Clinics, Karolinska Sjukhuset and King Gustav Vth Research Institute, Stockholm

来源：

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 1969年 / 23卷 / 04期

关键词：

Blood flow; Intra-arterial infusion; Noradrenaline; Vasodilatation;

D O I：

10.3109/00365516909081700

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In nine healthy male volunteers, the effect on forearm blood flow of infusions of prostaglandin E1 (PGE1) in the brachial artery was studied by means of strain-gauge plethysmography. PGE1 invariably caused a rapid local increase in blood flow with doses of 10-5 - 10-4 μg · min-1 · kg-1. With 10-2 μg · min-1 · kg-1 of PGE1, the forearm blood flow increased to an average of 30 ml · min-1 · 100 ml-1 (range 15-43). The PGE1-induced vasodilatation was not blocked by atropine or propranolol, but could be abolished by simultaneous infusion of noradrenaline. © 1969 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：347 / &

共 18 条

[1] BIOLOGICAL EFFECTS OF AN UNSATURATED TRIHYDROXY ACID (PGF2ALPHA) FROM NORMAL SWINE LUNG - PROSTAGLANDIN AND RELATED FACTORS 13
ANGGARD, E
BERGSTROM, S
[J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1963, 58 (01): : 1 - &
[2] PROSTAGLANDINS
BERGSTRO.S
SAMUELSS.B
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1965, 34 : 101 - &
[3] CARDIOVASCULAR AND METABOLIC RESPONSE TO INFUSIONS OF PROSTAGLANDIN E AND TO SIMULTANEOUS INFUSIONS OF NORADRENALINE AND PROSTAGLANDIN E IN MAN - PROSTAGLANDIN AND RELATED FACTORS 35
BERGSTROM, S
CARLSON, LA
EKELUND, LG
ORO, L
[J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1965, 64 (04): : 332 - +
[4] CIRCULATORY AND RESPIRATORY EFFECTS OF DIFFERENT DOSES OF PROSTAGLANDIN E1 IN MAN
CARLSON, LA
EKELUND, LG
ORO, L
[J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1969, 75 (1-2): : 161 - &
[5] EFFECT OF PROSTAGLANDIN E1 ON BLOOD PRESSURE AND HEART RATE IN DOG - PROSTAGLANDIN AND RELATED FACTORS 48
CARLSON, LA
ORO, L
[J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1966, 67 (01): : 89 - &
[6] CARLSON LA, 1968, ACTA MED SCAND, V183, P423
[7] EFFECTS OF PROSTAGLANDINS E1 AND E2 ON SMOOTH MUSCLE OF DOG SPLEEN AND ON ITS RESPONSES TO CATECHOLAMINES ANGIOTENSIN AND NERVE STIMULATION
DAVIES, BN
WITHRINGTON, PG
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1968, 32 (01) : 136 - +
[8] Euler U. S.v., 1935, KLIN WOCHENSCHR, V14, P1182, DOI DOI 10.1007/BF01778029
[9] Euler U.S.v., 1934, ARCH EXP PATHOL PH, V175, P78, DOI 10.1007/BF01861161
[10] Goldblatt M. W, 1933, J SOC CHEM IND LOND, V52, P1056

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