STUDY TO KNOW IMPAIRED GLUCOSE TOLERANCE AND ELEVATED SERUM URIC ACID LEVELS RELATION WITH METABOLIC SYNDROME

Metabolic syndrome (MetS) is a group of disorders including high blood sugar, increased blood pressure, abnormal cholesterol, excess body fat around the waist or triglyceride levels that occur together, increasing your risk of stroke, diabetes and heart disease causing cardio-metabolic risk factors. People having cardiovascular diseases have high serum uric acid levels with mostly MetS features. The importance of high uric acid levels pathogenesis in MetS and the development of diabetes mellitus type 2 (DM) has not been fully understood. Objective: The purpose of the study was to determine relationship between MetS criteria and oral glucose tolerance test (OGTT) and serum uric acid levels results was investigated. Study Design: A prospective Study. Place and Duration: In the Endocrinology Department of Services Hospital, Lahore for 1 year Duration from August 2016 to August 2017. Methodology: 83 patients with at least 3 MetS diagnostic criteria approved by the National Adult Treatment Panel were selected for study. Fasting venous blood samples were collected for 12 hours followed by 2 hours of OGTT with oral glucose of 75 g. BSR levels between 140 and 200 mg /dl at 2 hours was defined positive for GTT. Findings: 25 of 83 patients (31%) had a glucose value of 140 mg /dl or more for 2 hours. In multiple linear regression analysis, waist circumference and uric acid, 2-hour OGTT levels and body mass index were found to be significantly important. Conclusion: In this study, we found that some MetS-related uric acid levels were found in cases with high risk of type 2 DM. Uric acid concentrations did not affect insulin sensitivity and baseline blood glucose.