EFFECT OF SODIUM FLUORIDE AND/OR SODIUM IODATE ON BLOOD SUGAR RESPONSE TO THIOPENTAL IN FASTED RABBIT

The intraperitoneal administration of sodium thiopental, 40 mg./kg., to young male New Zealand white rabbits pre‐treated for 2 days with either Philadelphia tap water, distilled water, or Springfield water ad libitum and fasted 24 hr. prior to glycemic determinations induced hyperglycemia. The most marked hyperglycemic response occurred in those animals pretreated with Philadelphia tap water, which contains sodium fluoride (0.92 mg./l.), to which sodium iodate had been added (0.2%). The addition of sodium fluoride to either distilled water or Springfield water, employed in the 2‐day pretreatment period, resulted in greater hyperglycemia after thiopental than was noted when either type of water, devoid of fluoride, was utilized. Marked hypoglycemia occurred in response to thiopental in the group which received distilled water to which sodium iodate had been added. The presence of both halogens in the pretreatment liquid regimen, regardless of the kind of water used, resulted in hyperglycemia in response to thiopental. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company