CYCLOSPORINE IN THE TREATMENT OF CORTICOSTEROID RESISTANT AUTOIMMUNE CHRONIC ACTIVE HEPATITIS

被引：52
作者：
JACKSON, LD
SONG, E
机构：
[1] UNIV WITWATERSRAND,DEPT MED,DIV GASTROENTEROL,JOHANNESBURG 2001,SOUTH AFRICA
[2] UNIV WITWATERSRAND,DEPT MED,DIV HEPATOL,JOHANNESBURG 2001,SOUTH AFRICA
来源：
GUT | 1995年 / 36卷 / 03期
基金：
美国国家科学基金会;
关键词：
CYCLOSPORINE; HEPATITIS; CORTICOSTEROID RESISTANCE;
D O I：
10.1136/gut.36.3.459
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
A 17 year old Asian patient with autoimmune chronic active hepatitis resistant to treatment with high dose corticosteroids and azathioprine was given cyclosporin at a dose of 5 mg/kg/day. Within two weeks of starting the cyclosporin treatment a favourable clinical and biochemical response was obtained and by one month serum aminotransferase activities were within normal limits. An attempted reduction in the daily dose of cyclosporin resulted in a relapse of the patient's disease. Remission was again attained by returning the dose of cyclosporin to 5 mg/kg/day. No significant side effects of the treatment have been shown. Cyclosporin seems to have a role in the treatment of corticosteroid resistant autoimmune chronic active hepatitis and its further evaluation is warranted.
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页码：459 / 461
页数：3
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