IMMUNOHISTOCHEMICAL ANALYSIS OF T-CELL PROLIFERATION IN NORMAL TONSIL AND B-CELL LYMPHOMA

被引：7

作者：

WANG, J ^{[1
]}

ISAACSON, PG ^{[1
]}

SPENCER, J ^{[1
]}

机构：

[1] UCL, SCH MED, DEPT HISTOPATHOL, LONDON WC1E 6JJ, ENGLAND

来源：

JOURNAL OF CLINICAL PATHOLOGY | 1995年 / 48卷 / 09期

关键词：

T CELL; B CELL; LYMPHOMA; PROLIFERATION;

D O I：

10.1136/jcp.48.9.873

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

A double immunohistochemical technique, incorporating MIB1 and CD3, was used to identify proliferating T cells in paraffin wax sections of normal tonsil and B cell lymphomas. The number of double stained T cells as a percentage of the total T cells was then determined, In normal tonsil and follicular lymphoma the follicle centre and T cell zones were counted independently. In normal tonsil very few T cells in the follicle centre expressed MIB1. Proliferating T cells were concentrated in the T cell zones. The same pattern was observed in follicular lymphoma. In contrast, the percentage of T cells expressing MIB1 was higher in mucosa associated lymphoid tissue type lymphoma and lymphocytic lymphoma, suggesting that T cell activation occurs in these tumours, The highest percentage of MIB1 positive T cells was observed in high grade lymphoma, This suggests that transformation to high grade lymphoma is associated with an increase in T cell activation.

引用

页码：873 / 875

页数：3

共 11 条

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