YB-1 Activities in Oncogenesis: Transcription and Translation

被引：3

作者：

Bader, Andreas G. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol & Expt Med, 10550 North Torrey Pines Rd,BCC 239, La Jolla, CA 92037 USA

来源：

CURRENT CANCER THERAPY REVIEWS | 2006年 / 2卷 / 01期

关键词：

Y box; DbpB; p50; NSEP-1; EF-IA; mRNP;

D O I：

10.2174/157339406775471786

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Y box-binding protein 1 (YB-1) is a multifunctional DNA/RNA-binding protein regulating transcriptional and translational processes. Emerging evidence suggests a role for YB-1 in malignant human disease. Protein expression levels of YB-1 are increased in numerous human cancers, and nuclear YB-1 correlates with poor prognosis of tumor patients. However, YB-1 has also anti-oncogenic activities and interferes with phosphoinositide 3-kinase dependent cellular transformation. The anti-oncogenic activity correlates with cytoplasmic localization and with inhibition of protein synthesis. This review seeks to highlight the transcriptional and translational functions of YB-1 and its role in oncogenesis.

引用

页码：31 / 39

页数：9

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