MELATONIN AND CORTISOL SECRETION IN PATIENTS WITH PRIMARY OBSESSIVE-COMPULSIVE DISORDER

被引：54

作者：

CATAPANO, F ^{[1
]}

MONTELEONE, P ^{[1
]}

FUSCHINO, A ^{[1
]}

MAJ, M ^{[1
]}

KEMALI, D ^{[1
]}

机构：

[1] UNIV NAPLES,SCH MED 1,INST PSYCHIAT,LARGO MADONNA GRAZIE,I-80138 NAPLES,ITALY

来源：

PSYCHIATRY RESEARCH | 1992年 / 44卷 / 03期

关键词：

NOREPINEPHRINE; PINEAL GLAND; COMPULSIONS; CIRCADIAN RHYTHM; CORTISOL;

D O I：

10.1016/0165-1781(92)90025-X

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Plasma levels of melatonin and cortisol were measured over a 24-hour period in seven patients with primary obsessive-compulsive disorder (OCD) and seven matched healthy control subjects. In OCD patients, the 24-hour secretion of melatonin was reduced as compared with that in healthy control subjects, whereas its circadian rhythm was preserved. In addition, in OCD patients, the overall secretion of cortisol was higher than that in control subjects, but there was no change in the circadian pattern of cortisol secretion. No correlation was found between clinical parameters and hormone levels.

引用

页码：217 / 225

页数：9

共 33 条

[1]

ARENDT J, 1987, ADV PINEAL RES, V2, P223

[2]

ASBERG M, 1982, PSYCHOPHARMACOL BULL, V18, P13

[3]

BECKFRIIS J, 1983, PSYCHOPHARMACOL BULL, V19, P646

[4]

BECKFRIIS J, 1991, PSYCHOPHARMACOLOGY B, V37, P321

[5] PLASMA-CATECHOLAMINES AND THEIR METABOLITES IN OBSESSIVE-COMPULSIVE DISORDER [J].

BENKELFAT, C ;

MEFFORD, IN ;

MASTERS, CF ;

NORDAHL, TE ;

KING, AC ;

COHEN, RM ;

MURPHY, DL .

PSYCHIATRY RESEARCH, 1991, 37 (03) :321-331

[6] METYRAPONE - AN AGENT FOR MELATONIN AS WELL AS ACTH AND CORTISOL SECRETION [J].

BRISMAR, K ;

WERNER, S ;

THOREN, M ;

WETTERBERG, L .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 1985, 8 (02) :91-95

[7] DEXAMETHASONE SUPPRESSION TEST IN PATIENTS WITH PRIMARY OBSESSIVE-COMPULSIVE DISORDER AND IN HEALTHY CONTROLS [J].

CATAPANO, F ;

MONTELEONE, P ;

MAJ, M ;

KEMALI, D .

NEUROPSYCHOBIOLOGY, 1990, 23 (02) :53-56

[8]

CLAUSTRAT B, 1984, BIOL PSYCHIAT, V19, P1215

[9] ABNORMAL DEXAMETHASONE SUPPRESSION TEST IN PRIMARY OBSESSIVE-COMPULSIVE PATIENTS - A CONFIRMATORY REPORT [J].

COTTRAUX, JA ;

BOUVARD, M ;

CLAUSTRAT, B ;

JUENET, C .

PSYCHIATRY RESEARCH, 1984, 13 (02) :157-165

[10] INFLUENCE OF DEXAMETHASONE ON NOCTURNAL MELATONIN PRODUCTION IN HEALTHY ADULT SUBJECTS [J].

DEMISCH, L ;

DEMISCH, K ;

NICKELSEN, T .

JOURNAL OF PINEAL RESEARCH, 1988, 5 (03) :317-322

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