VIRAL INVOLVEMENT IN HODGKINS-DISEASE - DETECTION OF CLONAL TYPE-A EPSTEIN-BARR-VIRUS GENOMES IN TUMOR SAMPLES

被引：79

作者：

GLEDHILL, S

GALLAGHER, A

JONES, DB

KRAJEWSKI, AS

ALEXANDER, FE

KLEE, E

WRIGHT, DH

OBRIEN, C

ONIONS, DE

JARRETT, RF

机构：

[1] UNIV GLASGOW,SCH VET,CTR LEUKAEMIA RES FUND VIRUS,DEPT VET PATHOL,BEARSDEN RD,GLASGOW G61 1QH,SCOTLAND

[2] UNIV SOUTHAMPTON,SOUTHAMPTON GEN HOSP,DEPT PATHOL,SOUTHAMPTON S09 4XY,ENGLAND

[3] UNIV EDINBURGH,SCH MED,DEPT PATHOL,EDINBURGH EH8 9AG,MIDLOTHIAN,SCOTLAND

[4] UNIV LEEDS,LEUKAEMIA RES FUND CTR CLIN EPIDEMIOL,LEEDS LS2 9NG,W YORKSHIRE,ENGLAND

[5] UNIV LEEDS,DEPT PATHOL,LEEDS LS2 9NG,W YORKSHIRE,ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1991年 / 64卷 / 02期

关键词：

D O I：

10.1038/bjc.1991.281

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thirty-five cases of Hodgkin's disease (HD) were analysed for the presence of Epstein-Barr virus (EBV) and human herpesvirus-6 (HHV-6) DNA. EBV genomes were detected in 11/35 cases while none of the cases was positive for HHV-6. Ten of the EBV-positive cases were subsequently analysed using a probe for the terminal region of the virus; the results suggested that the EBV-infected cells were clonally expanded. EBV subtype specific DNA amplification was used to demonstrate that EBV subtype A, and not subtype B was present in the EBV-positive cases. The age distribution of the EBV-positive cases indicated a statistically significant trend for an increase in positivity with increasing age. This is the first indication that EBV is significantly associated with any subset of HD patients.

引用

页码：227 / 232

页数：6

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