TEMPORAL STUDY OF CARRAGEENAN-INDUCED PMN MIGRATION IN MICE

被引:9
作者
GARRELLY, L
BUREAU, JP
LABREQUE, G
机构
[1] CHU LAVAL,ECOLE PHARM,QUEBEC CITY G1K 7P4,QUEBEC,CANADA
[2] CHU LAVAL,DEPT PHARM,QUEBEC CITY G1K 7P4,QUEBEC,CANADA
来源
AGENTS AND ACTIONS | 1991年 / 33卷 / 3-4期
关键词
PAW EDEMA; INHIBITION; RAT; CHRONOBIOLOGY; INFLAMMATION; NEUTROPHILS;
D O I
10.1007/BF01986566
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The time course of polymorphonuclear neutrophil (PMN) migration in an experimental inflammatory granuloma induced by carrageenan in the mice was studied at 6 different times of the day. Compared to saline, the number of PMN increased as soon as 240 min and reached high level at 480 min when migration was induced by carrageenan. The data showed circadian variations in the time course of cell migration. After 240 and 360 minutes of migration, the number of PMN was highest in the cell trap implanted at 09.00 whereas minimum values were obtained at 01.00. After 480 minutes of implantation, the PMN migration was maximal when the carrageenan experiment was performed at 05.00 and minimum values were obtained at 13.00. Thus, a significant rhythm was demonstrated in the time course of PMN migration.
引用
收藏
页码:225 / 228
页数:4
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