Efficient Synthesis of beta-Lactam-Containing alpha-Aminophosphonates using Fumaric Acid as Mild Catalyst(phi)

被引：3

作者：

Vangala, Vijaya Bhaskar ^{[1
]}

Pati, Hari Narayan ^{[1
]}

机构：

[1] Eurofins Advinus Ltd, Dept Chem, 21 & 22,Phase 2, Bengaluru 560058, Karnataka, India

来源：

CHEMICAL METHODOLOGIES | 2018年 / 2卷 / 04期

关键词：

Fumaric acid; alpha-aminophosphonate ester; beta-lactam;

D O I：

10.22034/CHEMM.2018.66128

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A short and efficient protocol for the synthesis of novel alpha-aminophosphonate esters containing beta-lactam moiety is described. Inexpensive and mild acid catalyst such as fumaric acid was used for the synthesis of alpha-aminophosphonate esters by reacting N-(4-methoxyphenyl)-2-(substituted) propiolactam-3-carbaldehyde with amine and triethylphosphite in acetonitrile under reflux conditions. alpha-aminophosphonate esters containing beta-lactam hybrids were obtained in moderate to good yield and purity.

引用

页码：333 / 340

页数：8

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