2 COMPONENTS OF LONG-TERM POTENTIATION INDUCED BY DIFFERENT PATTERNS OF AFFERENT ACTIVATION

被引：593

作者：

GROVER, LM

TEYLER, TJ

机构：

[1] Neurobiology Department, Northeastern Ohio Universities College of Medicine, Rootstown

来源：

NATURE | 1990年 / 347卷 / 6292期

关键词：

D O I：

10.1038/347477a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

LONG-TERM potentiation (LTP) of excitatory synaptic transmission1-4 could be a mechanism underlying memory3,5. Induction of LTP requires Ca2+ influx into postsynaptic neurons6 through ion channels gated by NMDA (N-methyl-D-aspartate) receptors in hippocampus (area CA17,8 and dentate gyrus9) and neocortex10. Here we report that a component of LTP not requiring the activation of NMDA receptors can be induced in area CA1. The component is dependent on tetanus frequency, requires increases in postsynaptic intracellular Ca2+ concentrations, and is suppressed by an antagonist of voltage-dependent Ca2+ channels. © 1990 Nature Publishing Group.

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页码：477 / 479

页数：3

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