STRUCTURAL MARKERS ON CORE PROTEIN P-30 OF MURINE LEUKEMIA-VIRUS - FUNCTIONAL CORRELATION WITH FV-1 TROPISM

被引：68

作者：

GAUTSCH, JW ^{[1
]}

ELDER, JH ^{[1
]}

SCHINDLER, J ^{[1
]}

JENSEN, FC ^{[1
]}

LERNER, RA ^{[1
]}

机构：

[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1978年 / 75卷 / 09期

关键词：

D O I：

10.1073/pnas.75.9.4170

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tryptic peptide maps from more than 50 isolates of murine leukemia virus (MuLV) have shown that, in general, the structure of core protein p30 is highly conserved. However, a structurally variable region of p30 has been identified that is functionally associated with Fv-1 tropism. On the basis of this structural variability, MuLV strains can be classified as B-tropic, N-tropic, xenotropic, and/or as being derived from wild mice. Certain xenotropic viruses have a p30 like that of B-tropic MuLV and presumably would be subject to restriction in cells containing an Fv-1(n) allele. Other p30 structural markers serve to distinguish the exogenous Friend, Moloney, and Rauscher viruses from endogenous MuLV. Furthermore, some MuLV strains have structural differences in their p30s that are useful as strain-specific markers. Finally, a possible sarcoma-associated alteration in the structure of p30 has been noted in the m1 clone of Moloney murine sarcoma virus.

引用

页码：4170 / 4174

页数：5

共 38 条

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