Contents and Formulations of Platelet-Rich Plasma

被引：117
作者：
Wasterlain, Amy S. [1 ]
Braun, Hillary J. [1 ]
Dragoo, Jason L. [1 ]
机构：
[1] Stanford Univ, Dept Orthopaed Surg, Palo Alto, CA 94304 USA
来源：
OPERATIVE TECHNIQUES IN ORTHOPAEDICS | 2012年 / 22卷 / 01期
关键词：
platelet-rich plasma; contents; mechanism; composition; formulation;
D O I：
10.1053/j.oto.2011.11.001
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Multiple studies have demonstrated a role for platelet-rich plasma (PRP) in accelerating and facilitating improved response to injury. The cellular response to injury progresses through 4 general stages: hemostasis, inflammation, proliferation, and finally remodeling. Each phase is characterized by enhanced cellular or molecular activity, all of which involve platelets. Blood plasma and platelets are responsible for hemostasis, whereas leukocytes and activated platelets mediate inflammation, and growth factors derived from platelet alpha-granules influence tissue regeneration. Specifically, the leukocyte content of PRP is thought to influence the inflammatory phase, whereas angiogenic and mitogenic growth factor concentrations are believed to aid tissue regeneration. Both the precise composition of PRP and its formulation affect the cellular environment in which it is placed and determine its overall effect on tissue repair. (C) 2012 Elsevier Inc. All rights reserved.
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收藏
页码：33 / 42
页数：10
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