LEVODOPA FAILURE IN CHRONIC MANGANISM

被引：88

作者：

LU, CS

HUANG, CC

CHU, NS

CALNE, DB

机构：

[1] CHANG GUNG MEM HOSP,TAIPEI 10591,TAIWAN

[2] UNIV BRITISH COLUMBIA,CTR NEURODEGENERAT DISORDERS,VANCOUVER,BC,CANADA

来源：

NEUROLOGY | 1994年 / 44卷 / 09期

关键词：

D O I：

10.1212/WNL.44.9.1600

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report a placebo-controlled study of levodopa in four patients with extrapyramidal deficits caused by chronic manganese intoxication. Their parkinsonism and dystonia had progressed slowly over a period of 5 years after they left the site of exposure. Initially the patients appeared to respond to levodopa in open observations, but this apparent benefit was not sustained. This short-term, double-blind study indicates that their parkinsonism and dystonia failed to respond to levodopa.

引用

收藏

页码：1600 / 1602

页数：3

相关论文

共 18 条

[1]

BERNHEIMER H, 1973, J NEUROL SCI, V20, P415, DOI 10.1016/0022-510X(73)90175-5

[2] CHRONIC MANGANESE INTOXICATION [J].

COOK, DG ;

FAHN, S ;

BRAIT, KA .

ARCHIVES OF NEUROLOGY, 1974, 30 (01) :59-64

[3] METABOLIC MODIFICATION OF PARKINSONS DISEASE AND OF CHRONIC MANGANESE POISONING [J].

COTZIAS, GC ;

PAPAVASILIOU, PS ;

GINOS, J ;

STECK, A ;

DUBY, S .

ANNUAL REVIEW OF MEDICINE, 1971, 22 :305-+

[4]

DUVOISIN RC, 1970, MONOAMINES NOYAUX GR, P313

[5] MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].

FOLSTEIN, MF ;

FOLSTEIN, SE ;

MCHUGH, PR .

JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198

[6]

Greenhouse A H, 1971, Trans Am Neurol Assoc, V96, P248

[7] PROGRESSION AFTER CHRONIC MANGANESE EXPOSURE [J].

HUANG, CC ;

LU, CS ;

CHU, NS ;

HOCHBERG, F ;

LILIENFELD, D ;

OLANOW, W ;

CALNE, DB .

NEUROLOGY, 1993, 43 (08) :1479-1483

[8] CHRONIC MANGANESE INTOXICATION [J].

HUANG, CC ;

CHU, NS ;

LU, CS ;

WANG, JD ;

TSAI, JL ;

TZENG, JL ;

WOLTERS, EC ;

CALNE, DB .

ARCHIVES OF NEUROLOGY, 1989, 46 (10) :1104-1106

[9] CHRONIC MANGANESE POISONING - CLINICAL PICTURE AND MANGANESE TURNOVER [J].

MENA, I ;

MARIN, O ;

FUENZALIDA, S ;

COTZIAS, GC .

NEUROLOGY, 1967, 17 (02) :128-+

[10] MODIFICATION OF CHRONIC MANGANESE POISONING . TREATMENT WITH L-DOPA OR 5-OH TRYPTOPHANE [J].

MENA, I ;

COURT, J ;

FUENZALIDA, S ;

PAPAVASILIOU, PS ;

COTZIAS, GC .

NEW ENGLAND JOURNAL OF MEDICINE, 1970, 282 (01) :5-+