CYTOGENETIC DAMAGE OF BONE-MARROW CELLS PRODUCED BY CHRONIC ALCOHOL-CONSUMPTION

被引：21

作者：

BARAONA, E ^{[1
]}

GUERRA, M ^{[1
]}

LIEBER, CS ^{[1
]}

机构：

[1] CUNY MT SINAI SCH MED, NEW YORK, NY 10029 USA

来源：

LIFE SCIENCES | 1981年 / 29卷 / 17期

关键词：

D O I：

10.1016/0024-3205(81)90191-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Pair-feeding of rats with nutritionally adequate liquid diets containing 36% of total energy as ethanol or as additional carbohydrate (in controls) resulted in blood ethanol concentrations similar to those observed in alcoholics. Alcohol feeding for 6 wk increased the frequency of micronuclei in bone marrow erythrocytes, an index of chromosomal damage in precursor cells. This was associated with bone marrow hypoplasia and erythrocyte macrocytosis, alterations commonly found in alcoholics. Acute ethanol administration produced no changes in bone marrow. Cytogenetic damage of stem cells could lead to alterations persisting after alcohol withdrawal beyond the life span of effector cells.

引用

页码：1797 / 1802

页数：6

共 47 条

[1] ETHANOL INDUCTION OF SISTER CHROMATID EXCHANGES IN HUMAN-CELLS INVITRO [J].