ENANTIOSPECIFIC SYNTHESIS OF [(2'S, 3'S)-BIS(HYDROXYMETHYL)AZETIDIN-1-YL] PYRIMIDINE NUCLEOSIDES AS POTENTIAL ANTIVIRAL AGENTS

被引：16
作者：
HOSONO, F
NISHIYAMA, S
YAMAMURA, S
IZAWA, T
KATO, K
TERADA, Y
机构：
[1] KEIO UNIV,FAC SCI & TECHNOL,DEPT CHEM,YOKOHAMA,KANAGAWA 223,JAPAN
[2] MEIJO UNIV,FAC PHARM,TEMPAKU KU,NAGOYA,AICHI 468,JAPAN
来源：
TETRAHEDRON | 1994年 / 50卷 / 47期
关键词：
D O I：
10.1016/S0040-4020(01)89342-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The enantiospecific synthesis of [(2'S, 3'S)-bis(hydroxymethyl)azetidin-1-yl]pyrimidine nucleosides 22,25, and 27 was achieved via construction of the base on the 1-aminoazetidine 18 prepared from (+)-diethyl-L-tartrate, and they are the first members of a new class of nucleoside analogs in which the oxetane ring in oxetanocin-A 4 is replaced by an azetidine ring linked to a nucleic base through an N-N bond.
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页码：13335 / 13346
页数：12
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