GnRH-antagonists in gynecology: First results within controlled ovarian hyperstimulation (COH)

被引：4

作者：

Felberbaum, R ^{[1
]}

Reissmann, T ^{[1
]}

Zoll, C ^{[1
]}

Kupker, W ^{[1
]}

AlHasani, S ^{[1
]}

Diedrich, C ^{[1
]}

Diedrich, K ^{[1
]}

机构：

[1] ASTA MED AG,W-6000 FRANKFURT,GERMANY

来源：

GYNAKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU | 1995年 / 35卷

关键词：

GnRH; GnRH-antagonists; premature LH-surge; competitive blockage; pituitary; response;

D O I：

10.1159/000272579

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: Applicability of the GnRH-antagonist Cetrorelix within controlled ovarian hyperstimulation (COH) to avoid the premature LH-surge should be examined. Methods: 35 patients suffering from tubal infertility were stimulated for In Vitro Fertilization (IVF) by human menopausal gonadotrophins (HMG) and concomitant administration of Cetrorelix in different dosages (3 mg, 1 mg, 0,5 mg). Results: No premature LH-surge could be observed. Conclusions: Short term administration of the GnGR-antagonists avoids the occurance of a premature LH-surge.

引用

页码：113 / 117

页数：5

共 23 条

[1] SUSTAINED SUPPRESSION OF SERUM LH, FSH AND TESTOSTERONE AND INCREASE OF HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL BY DAILY INJECTIONS OF THE GNRH ANTAGONIST CETRORELIX OVER 8 DAYS IN NORMAL MEN [J].