SERUM LAMININ IN LIVER-DISEASE - AN ENZYME-IMMUNOASSAY STUDY

被引：3

作者：

GAO, F

KONG, XT

XIE, YH

机构：

[1] Department of Clinical Immunology, Changzheng Hospital, Shanghai

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 1994年 / 6卷 / 07期

关键词：

LAMININ; IMMUNOASSAY; ANTIBODY; EXTRACELLULAR MATRIX; LIVER DISEASE;

D O I：

10.1097/00042737-199407000-00013

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objective: To quantify the diagnostic Power of serum laminin as a marker of liver cirrhosis. Design: An enzyme-linked immunosorbent assay for measuring serum laminin was developed and sera from 127 patients with hepatitis of differing etiology were assayed. The results were compared with those from healthy controls and patients without hepatic disease. Results: All patients with chronic hepatic disease had high-serum laminin levels, with the highest level being found in those with liver cirrhosis. There was no increase in serum laminin levels in patients with acute hepatitis, non-hepatic disease, and positive hepatitis B virus carriers. Conclusion: Determination of serum laminin levels may be helpful for the diagnosis of liver cirrhosis caused by viral hepatitis.

引用

页码：629 / 632

页数：4

共 22 条

[11]

Nakayama Y., Takahara T., Miyabayashi C., Itoh H., Watanabe A., Sasaki H., Et al., Ultrastructurallocalization of type TV collagen and laminin in the Disse space of rat liver with carbon tetrachloride induced fibrosis, Liver, 11, pp. 260-271, (1991)

[12]

Niemela O., Risteli L., Sotaniemi E.A., Risteli J., Type IV collagen and laminin-related antigens in human serum in alcoholic liver disease, Eur J Clin Invest, 15, pp. 132-137, (1985)

[13]

Nouchi T., Worner T.M., Sato Slieber C.S., Serum procollagen type IIIN-terminal peptides and laminin P 1peptide in alcoholic liver disease, Alcohol Clin Exp Res, 11, pp. 287-291, (1987)

[14]

Gressner A.M., Kropf J., Concentration of laminin in serum related to the degree of esophageal varices in fibrotic liver diseases, Clin Chem, 34, pp. 1005-1006, (1988)

[15]

Misaki M., Shima T., Yano Y., Sumita Y., Kano U., Murata T., Et al., Basement membrane-related and type III procollagen-related antigens in serum of patients with chronic viral liver disease, Clin Chem, 36, pp. 522-524, (1990)

[16]

Plebani M., Burlina A., Biochemical markers of hepatic fibrosis, Clin Biochem, 24, pp. 219-239, (1991)

[17]

Lotterer E., Gressner A., Kropf J., Grobe E., Von-Knebel D., Bircher J., High levels of serum aminoterminal type III procollagen peptide, and laminin in alcoholic than in nonalcoholic cirrhosis of equal severity, J Hepatol, 14, pp. 71-77, (1992)

[18]

Jones P.A., De Clerk Y.A., Extracellular matrix destruction by invasive tumor cells, Cancer Metastasis Rev, 1, pp. 289-317, (1982)

[19]

Thorgeirsson U.P., Turpeenniemi-Hujanen T., Liotta L.A., Cancer cells, components of basement membranes and proteolytic enzymes, Int Rev Exp Pathol, 27, pp. 203-234, (1985)

[20]

Herrmann K., Schulze E., Heckmann M., Schubert I., Meurer M., Ziegler V., Et al., Type III collagen aminopropeptide and laminin PI levels in serum of patients with silicosis-associ-ated idiopathic systemic scleroderma, Br J Dermatol, 123, pp. 1-7, (1990)

← 1 2 3 →