SYNTHESIS OF THE ANTITUMOR AGENT CI-973 ([SP-4-3-(R)]-[1,1-CYCLOBUTANEDICARBOXYLATO(2)](2-METHYL-1,4-[4-C-14]BUTANEDIAMINE-N,N')PLAINUM)

被引：0

作者：

EKHATO, IV ^{[1
]}

HOESCHELE, JD ^{[1
]}

HUANG, CC ^{[1
]}

NANAVATY, B ^{[1
]}

LEE, HT ^{[1
]}

机构：

[1] WARNER LAMBERT PARKE DAVIS,PARKE DAVIS PHARMACEUT RES,DEPT CHEM,ANN ARBOR,MI 48105

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1993年 / 33卷 / 12期

关键词：

([SP-4-3-(R)]-[1,1-CYCLOBUTANEDICARBOXYLATO(2)](2-METHYL-1,4-BUTANE-N,N')PLATINUM); (R)-(+)-2-METHYL-1; J-BUTANEDIAMINE; ANTITUMOR DRUG; SILVER 1,1-CYCLOBUTANEDICARBOXYLATE; SQUARE-PLANAR DIAMINOPLATIUM (II) CHELATE COMPLEX;

D O I：

10.1002/jlcr.2580331202

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Starting from the chiral compound 1, (R)-(+)-2-methyl-1,4-[C-14]butanediamine 7 was synthesized in a sequence of reactions in which C-14-label was introduce using label potassium cyanide. Compound 7 was reacted with potassium tetraiodoplatinate and silver 1,1-cyclobutanedicarboxylate to make the title compound {[SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2)](2-methyl-1,4-butanediamine-N, N')platinum} 11.

引用

页码：1083 / 1089

页数：7

共 6 条

[1] HUDES G R, 1991, Proceedings of the American Association for Cancer Research Annual Meeting, V32, P199
[2] MATTINGLY PG, 1990, SYNTHESIS-STUTTGART, P366
[3] NOWATARI, 1987, Patent No. 2199361
[4] STEREOSPECIFICITY OF PIG-KIDNEY AND PEA SEEDLING DIAMINO OXIDASES ON 2-METHYL-1,4-DIAMINOBUTANE
SANTANIELLO, E
MANZOCCHI, A
BIONDI, PA
SECCHI, C
SIMONIC, T
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1984, (12) : 803 - 804
[5] GENERAL PROCEDURE FOR SYNTHESIS OF MONO-N-ACYLATED 1,6-DIAMINOHEXANES
STAHL, GL
WALTER, R
SMITH, CW
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1978, 43 (11) : 2285 - 2286
[6] VONBRAUN J, 1926, CHEM BER, V59, P1091

← 1 →