ALPHA-ADRENERGIC DRUGS INHIBIT [H-3] QNB BINDING TO MUSCARINIC RECEPTORS OF RAT-HEART, BRAIN AND PAROTID-GLAND MEMBRANES

被引：2
作者：
SIMON, G [1 ]
FILEP, J [1 ]
ZELLES, T [1 ]
机构：
[1] SEMMELWEIS UNIV MED,SCH MED,DEPT ORAL BIOL,H-1085 BUDAPEST 8,HUNGARY
来源：
LIFE SCIENCES | 1990年 / 47卷 / 22期
关键词：
D O I：
10.1016/0024-3205(90)90436-U
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Alpha adrenergic agonists and antagonists as clonidine, guanfacine, yohimbine, phenylephrine and prazosin inhibited the [3H]-QNB binding to rat brain cortex muscarinic acetylcholine receptor (mAChR, M-1 subtype), heart (M-2 subtype) and parotid gland homogenate (M-3 subtype) in a dose-dependent competitive fashion. Ki values were between 10-6 and 10-3 M. Hill coefficients were about 1. No correlation was found between mAChR inhibiting capacity of these drugs and their activity on alpha adrenergic receptors. In contrast, other transmitters, as dopamine, GABA, glutamic acid, histamine, serotonin, isoproterenol and platelet activating factor (PAF) did not affect the QNB binding. © 1990.
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页码：2021 / 2025
页数：5
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