VARYING RESPONSES OF CULTURED MAMMALIAN-CELL LINES TO THE CELLULAR DNA BREAKING ACTIVITY OF EPINEPHRINE

被引：11

作者：

YAMADA, K

MURAKAMI, H

NISHIGUCHI, H

SHIRAHATA, S

SHINOHARA, K

OMURA, H

机构：

[1] Department of Food Science and Technology, Kyushu University

来源：

AGRICULTURAL AND BIOLOGICAL CHEMISTRY | 1979年 / 43卷 / 05期

关键词：

D O I：

10.1080/00021369.1979.10863562

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

To clarify the mechanism of cellular DNA breakage with epinephrine (Ep), the relationship between the activities of14C-Ep incorporation and DNA breakages was studied by the use of three cultured cell lines: rat fetal lung, HcLa-S3 and L. Rat fetal lung cells which were the most sensitive to the lethal effect of Ep showed more remarkable incorporation of the radioactivity than the other cell lines and both single-strand and double-strand breaks were detected upon treatment with 25 μM Ep. This parallel relationship between the14C-Ep incorporation and the cellular DNA breaking activity of Ep suggests that the cellular DNA is broken by a direct attack of Ep on DNA and the development of the reaction is dependent on the cell line. © 1979 Taylor & Francis Group, LLC.

引用

页码：901 / 906

页数：6

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