Locotomor Activity, Learning and Memory in WAG/Rij Rats with Absence Epilepsy

被引：0
作者：
Karson, Ayse [1 ]
Onat, Filiz [2 ]
Balci, Fuat [3 ,4 ]
Ates, Nurbay [1 ]
机构：
[1] Kocaeli Univ, Fizyol Anabilim Dali, Kocaeli, Turkey
[2] Marmara Univ, Tip Fak, Farmakol Anabilim Dal, Istanbul, Turkey
[3] Rutgers State Univ, Dept Psychol, New Brunswick, NJ 08901 USA
[4] Rutgers State Univ, Rutgers Ctr Cognit Sci, New Brunswick, NJ 08901 USA
来源：
EPILEPSI | 2008年 / 14卷 / 03期
关键词：
Abscncc epilepsy; VVAG/Rij; rat; behavior; open field; passive avoidance; water maze; memory; locomotion;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objectives: The aim of this study was to evaluate the behavioral characteristics of WAG/Rij rats, a genetic model for absence epilepsy. Materials and methods: The performance of WAG/Rij rats in passive avoidance, Morris-water maze and open-field tests were compared with the Wistar rats (control group). Results: Passive avoidance and rota-rod performance did not differ between the two groups. WAG/Rij rats exhibited longer escape latencies on the first day of training in Morris water-maze, however, this difference disappeared with further training and during the probe day (without the platform). WAG/Rij rats exhibited increased locomotor activity in the open-field test. Discussion: Results are discussed with respect to known behavioral and cognitive deficits that characterize patients with absence epilepsy.
引用
收藏
页码：167 / 175
页数：9
相关论文
共 61 条
  • [1] Amphetamine-induced locomotion, behavioral sensitization to amphetamine, and striatal D2 receptor function in rats with high or low spontaneous exploratory activity:: Differences in the role of locus coeruleus
    Alttoa, Aet
    Eller, Marika
    Herm, Laura
    Rinken, Ago
    Harro, Jaanus
    [J]. BRAIN RESEARCH, 2007, 1131 (01) : 138 - 148
  • [2] The role of the thalamus in vigilance and epileptogenic mechanisms
    Avanzini, G
    Panzica, F
    de Curtis, M
    [J]. CLINICAL NEUROPHYSIOLOGY, 2000, 111 : S19 - S26
  • [3] Distribution of D1-like and D2-like dopamine receptors in the brain of genetic epileptic WAG/Rij rats
    Birioukova, LM
    Midzyanovskaya, IS
    Lensu, S
    Tuomisto, L
    van Luijtelaar, G
    [J]. EPILEPSY RESEARCH, 2005, 63 (2-3) : 89 - 96
  • [4] Cellular and network mechanisms of spike-wave seizures
    Blumenfeld, H
    [J]. EPILEPSIA, 2005, 46 : 21 - 33
  • [5] .1. Serotonin (5-HT) within dopamine reward circuits signals open-field behavior .2. Basis for 5-HT-DA interaction in cocaine dysfunctional behavior
    Broderick, PA
    Phelix, CF
    [J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1997, 21 (03) : 227 - 260
  • [6] D-amphetamine facilitation of Morris water task performance is blocked by eticlopride and correlated with increased dopamine synthesis in the prefrontal cortex
    Brown, RW
    Bardo, MT
    Mace, DD
    Phillips, SB
    Kraemer, PJ
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2000, 114 (1-2) : 135 - 143
  • [7] Altered responses to novelty and drug reinforcement in adult rats treated neonatally with domoic acid
    Burt, Melissa A.
    Ryan, Catherine L.
    Doucette, Tracy A.
    [J]. PHYSIOLOGY & BEHAVIOR, 2008, 93 (1-2) : 327 - 336
  • [8] Depression and anxiety disorders in pediatric epilepsy
    Caplan, R
    Siddarth, P
    Gurbani, S
    Hanson, R
    Sankar, R
    Shields, WD
    [J]. EPILEPSIA, 2005, 46 (05) : 720 - 730
  • [9] Childhood absence epilepsy: Behavioral, cognitive, and linguistic comorbidities
    Caplan, Rochelle
    Siddarth, Prabha
    Stahl, Lesley
    Lanphier, Erin
    Vona, Pamela
    Gurbani, Suresh
    Koh, Susan
    Sankar, Raman
    Shields, W. Donald
    [J]. EPILEPSIA, 2008, 49 (11) : 1838 - 1846
  • [10] Genetic animal models for absence epilepsy: A review of the WAG/Rij strain of rats
    Coenen, AML
    van Luijtelaar, ELJM
    [J]. BEHAVIOR GENETICS, 2003, 33 (06) : 635 - 655
1234567