SYNTHESIS OF NOVEL ISOTHIAZOLE AND ISOTHIAZOLO[4,5-D] PYRIMIDINE ANALOGS OF THE NATURAL C-NUCLEOSIDES PYRAZOFURIN AND THE FORMYCINS

被引：9

作者：

BUFFEL, DK ^{[1
]}

MEERPOEL, L ^{[1
]}

TOPPET, SM ^{[1
]}

HOORNAERT, GJ ^{[1
]}

机构：

[1] KATHOLIEKE UNIV LEUVEN,DEPT SCHEIKUNDE,ORGAN SYNTH LAB,B-3001 HEVERLEE,BELGIUM

来源：

NUCLEOSIDES & NUCLEOTIDES | 1994年 / 13卷 / 1-3期

关键词：

D O I：

10.1080/15257779408013275

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cycloaddition of tri-O-benzyl-2,5-anhydro-D-allononitrile-N-sulfide with dimethyl acetylenedicarboxylate or with dimethyl fumarate followed by DDQ oxidation was found to give the benzoyl protected dimethyl 3-beta-D-ribofuranosyl-isothiazoledicarboxylate 10. This compound was converted to C-nucleosides 7a, 8 and 9, analogues of pyrazofurin, oxoformycin B and formycin respectively. Despite their structural similarities they did show neither antiviral nor antitumor activity.

引用

页码：719 / 736

页数：18

共 76 条

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