ROLE OF ESTROGEN-RECEPTOR VARIANTS IN THE DEVELOPMENT OF HORMONE RESISTANCE IN BREAST-CANCER

被引:38
作者
SLUYSER, M
机构
[1] Division of Tumor Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam
关键词
ESTROGEN RECEPTOR VARIANTS; HORMONE DEPENDENCY; BREAST CANCER;
D O I
10.1016/0009-9120(92)90015-K
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Recent evidence suggests that the progression to hormone resistance in some breast tumors is due to mutations in the estrogen receptor (ER). Various types of ER variants have been found in breast cancer biopsies and breast cancer cell lines. The ER variants include dominant-positive receptors that are transcriptionally active in the absence of estrogen, and dominant-negative receptors that are themselves transcriptionally inactive but prevent the action of the normal receptor. The mechanisms by which these variants cause loss of hormonal control is becoming clear. ER variants may be prognostic factors for breast cancer. By modifying the action of ER variants, it should be possible to develop new strategies for treatment of malignant breast disease.
引用
收藏
页码:407 / 414
页数:8
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