A Potent 5-HT2A Receptor Agonist TCB-2 Exerts Rapid Antidepressant-Like and Anxiolytic-Like Effects in Mice

被引:0
作者
Koike, Hiroyuki [1 ]
Horinokita, Ichiro [1 ]
Suzuki, Mikio [1 ]
Futamura, Takashi [1 ]
机构
[1] Otsuka Pharmaceut Co Ltd, Tokushima 77101, Japan
关键词
Serotonin 5-HT2A Receptor; TCB-2; Psychedelics; Animal Models;
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
P360
引用
收藏
页码:270 / 271
页数:2
相关论文
共 43 条
  • [31] Effects of serotonin (5-HT)2 receptor ligands on depression-like behavior during nicotine withdrawal
    Zaniewska, Magdalena
    McCreary, Andrew C.
    Wydra, Karolina
    Filip, Malgorzata
    NEUROPHARMACOLOGY, 2010, 58 (07) : 1140 - 1146
  • [32] Inhibitor of Striatal-Enriched Protein Tyrosine Phosphatase, 8-(Trifluoromethyl)-1,2,3,4,5-Benzopentathiepin-6-Amine hydrochloride (TC-2153), Produces Antidepressant-Like Effect and Decreases Functional Activity and Protein Level of 5-HT2A Receptor in the Brain
    Kulikova, E. A.
    Khotskin, N., V
    Illarionova, N. B.
    Sorokin, I. E.
    Bazhenova, E. Y.
    Kondaurova, E. M.
    Volcho, K. P.
    Khomenko, T. M.
    Salakhutdinov, N. F.
    Ponimaskin, E.
    Naumenko, V. S.
    Kulikov, A., V
    NEUROSCIENCE, 2018, 394 : 220 - 231
  • [33] Anxiolytic-like effect of 5-HT2 ligands and benzodiazepines co-administration:: Comparison of two animal models of anxiety (the four-plate test and the elevated plus maze)
    Masse, Fabienne
    Dhonnchadha, Brid Aine Nic
    Hascoet, Martine
    Bourin, Michel
    BEHAVIOURAL BRAIN RESEARCH, 2007, 177 (02) : 214 - 226
  • [34] Antidepressant-like Effects Induced by Chronic Blockade of the Purinergic 2X7 Receptor through Inhibition of Non-like Receptor Protein 1 Inflammasome in Chronic Unpredictable Mild Stress Model of Depression in Rats
    Aricioglu, Feyza
    Ozkartal, Ceren Sahin
    Bastaskin, Tugce
    Tuzun, Erdem
    Kandemir, Cansu
    Sirvanci, Serap
    Kucukali, Cem Ismail
    Utkan, Tijen
    CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, 2019, 17 (02) : 261 - 272
  • [35] 1-(m-Chlorophenyl)piperazine induces depressogenic-like behaviour in rodents by stimulating the neuronal 5-HT2A receptors: Proposal of a modified rodent antidepressant assay
    Rajkumar, Ramamoorthy
    Pandey, Dilip Kumar
    Mahesh, Radhakrishnan
    Radha, Raghuraman
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2009, 608 (1-3) : 32 - 41
  • [36] 2-(4-substituted piperazin-1-yl)-1,8-naphthyridine-3-carboxylic acids: Novel 5-HT3 receptor antagonists with anxiolytic-like activity in rodent behavioral models
    Mahesh, Radhakrishnan
    Dhar, Arghya Kusum
    Jindal, Ankur
    Bhatt, Shvetank
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2013, 91 (10) : 848 - 854
  • [37] Discovery of Novel 5-HT2A Receptor Agonists With Psychedelic Drug-Like in Vitro and in Vivo Pharmacological Activity and Therapeutic Potential for Treatment-Resistant Depression
    Bowen, Carrie
    Khan, Tanweer
    Perni, Robert
    Aron, Rebecca
    Gibbs, Alan
    Shin, Rick
    Halberstadt, Adam
    Premoli, Isabella
    Kleine, Patrick
    Rao, Srinivas
    Short, Glenn
    NEUROPSYCHOPHARMACOLOGY, 2023, 48 : 275 - 275
  • [38] Antidepressant-like activity of (4-phenylpiperazin-1-yl) (quinoxalin-2-yl) methanone (4a), a novel 5-HT 3 receptor antagonist: An investigation in behaviour-based rodent models of depression
    Mahesh, Radhakrishnan
    Kumar, Baldev
    Jindal, Ankur
    Bhatt, Shvetank
    Devadoss, Thangaraj
    Pandey, Dilip Kumar
    INDIAN JOURNAL OF PHARMACOLOGY, 2012, 44 (05) : 560 - 565
  • [39] Antidepressant-like activity of 2-(4-phenylpiperazin-1-yl)-1, 8-naphthyridine-3-carboxylic acid (7a), a 5-HT3 receptor antagonist in behaviour based rodent models: Evidence for the involvement of serotonergic system
    Gautam, Baldev Kumar
    Jindal, Ankur
    Dhar, Arghya Kusum
    Mahesh, Radhakrishnan
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2013, 109 : 91 - 97
  • [40] Subjective and Pharmacodynamic Effects of the Novel 5-HT2A Receptor Agonist GM-2505 in Healthy Volunteers Show High Translatability From Rodent Data and Hold Promise for Future Development in Patients With Depression
    Hughes, Zoe
    Christian, Edward
    Dvorak, Dino
    Umbricht, Daniel
    Winters, Jason
    Raines, Shane
    Klein, Adam
    Austin, Eric
    Sporn, Jonathan
    Kiss, Laszlo
    Kruegel, Andrew
    Makai-Boloni, Soma
    Jacobs, Gabriel
    Marek, Gerard
    NEUROPSYCHOPHARMACOLOGY, 2023, 48 : 202 - 203