STRUCTURAL VARIATIONS OF N-ACETYLNEURAMINIC ACID .24. SYNTHESIS OF THE ALPHA-METHYLKETOSIDE OF 8-OXO-N-ACETYLNEURAMINIC ACID AND RELATED DERIVATIVES

被引：3
作者：
HARTMANN, M [1 ]
ZBIRAL, E [1 ]
机构：
[1] UNIV VIENNA,INST ORGAN CHEM,A-1090 VIENNA,AUSTRIA
来源：
MONATSHEFTE FUR CHEMIE | 1991年 / 122卷 / 11期
关键词：
SIALIC ACIDS; KETO-SUGARS; SYNTHESIS OF A METHYL GLYCOSIDE;
D O I：
10.1007/BF00823430
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis of the sodium 5-acetamido-2,3,5-trideoxy-2,3 didehydro-D-galacto-2,8-nondiulopyranosidonate 8,8-dimethyl acetal (8) and of the methyl-5-acetamido-3,5-dideoxy-alpha-D-galacto-2,8-nondiulopyranosidonate 8,8 dimethyl acetal (11) as well as of the methyl-5-acetamido-3,5-dideoxy-alpha-D-galacto-2,8-nondiulopyranosidonic acid (12) is reported involving the easily accessible 8-oxo-derivative 5. Compounds 11 and 12, respectively, showed to have glycosidic bond with remarkable stability to acidic conditions.
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页码：995 / 1003
页数：9
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