VOLTAGE-DEPENDENT CALCIUM AND POTASSIUM-ION CONDUCTANCES - CONTINGENCY MECHANISM FOR AN ASSOCIATIVE LEARNING-MODEL

被引：123
作者：
ALKON, DL
机构：
[1] Section on Neural Systems, Laboratory of Biophysics, National Institute of Neurological and Communicative Disorders and Stroke, Woods Hole
来源：
SCIENCE | 1979年 / 205卷 / 4408期
关键词：
D O I：
10.1126/science.223244
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Persistent light-induced depolarization results from Ca2+ influx across a photoreceptor membrane. The marked dependence on potential of this Ca2+ influx and a Ca2+-dependent K+ efflux accounts for enhancement of the light-induced depolarization when light is paired with rotation. A positive feedback cycle between light-induced depolarization and synaptic depolarization due to stimulus pairing can explain long-lasting behavioral changes produced by associative training but not control paradigms. The sensitivity of this Ca2+ influx to intracellular levels of adenosine 3′,5′-monophosphate suggests biochemical steps for this model of associative learning. Copyright © 1979 AAAS.
引用
收藏
页码：810 / 816
页数：7
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