MUSCLE-DERIVED NEUROTROPHIN-4 AS AN ACTIVITY-DEPENDENT TROPHIC SIGNAL FOR ADULT MOTOR-NEURONS

被引：313

作者：

FUNAKOSHI, H

BELLUARDO, N

ARENAS, E

YAMAMOTO, Y

CASABONA, A

PERSSON, H

IBANEZ, CF

机构：

[1] KAROLINSKA INST, DEPT MED BIOCHEM & BIOPHYS, MOLEC NEUROBIOL LAB, S-17177 STOCKHOLM, SWEDEN

[2] KAROLINSKA INST, NOBEL INST NEUROPHYSIOL, S-17177 STOCKHOLM, SWEDEN

[3] KAROLINSKA INST, INST WOMAN & CHILD HLTH, S-17177 STOCKHOLM, SWEDEN

[4] UNIV CATANIA, INST FISIOL HUMANA, CATANIA, ITALY

来源：

SCIENCE | 1995年 / 268卷 / 5216期

关键词：

D O I：

10.1126/science.7770776

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The production of neurotrophin-4 (NT-4) in rat skeletal muscle was found to depend on muscle activity. The amounts of NT-4 messenger RNA present decreased after blockade of neuromuscular transmission with alpha-bungarotoxin and increased during postnatal development and after electrical stimulation in a dose-dependent manner. NT-4 immunoreactivity was detected in slow, type I muscle fibers. Intramuscular administration of NT-4 induced sprouting of intact adult motor nerves. Thus, muscle-derived NT-4 acted as an activity-dependent neurotrophic signal for growth and remodeling of about motor-neuron innervation. NT-4 may thus be partly responsible for the effects of exercise and electrical stimulation on neuromuscular performance.

引用

页码：1495 / 1499

页数：5

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