IMMUNIZATION AGAINST PORPHYROMONAS-GINGIVALIS INHIBITS PROGRESSION OF EXPERIMENTAL PERIODONTITIS IN NONHUMAN-PRIMATES

被引：91

作者：

PERSSON, CR

ENGEL, D

WHITNEY, C

DARVEAU, R

WEINBERG, A

BRUNSVOLD, M

PAGE, RC

机构：

[1] UNIV WASHINGTON, SCH MED, ORAL BIOL RES CTR, DEPT PATHOL, SEATTLE, WA 98195 USA

[2] UNIV WASHINGTON, SCH DENT, DEPT PERIODONT, SEATTLE, WA 98195 USA

[3] UNIV WASHINGTON, SCH DENT, DEPT DENT PUBL HLTH SCI, SEATTLE, WA 98195 USA

[4] UNIV TEXAS, SCH DENT, DEPT PERIODONT, SAN ANTONIO, TX 78284 USA

[5] BRISTOL MYERS SQUIBB PHARMACEUT RES INST, SEATTLE, WA 98121 USA

来源：

INFECTION AND IMMUNITY | 1994年 / 62卷 / 03期

关键词：

D O I：

10.1128/IAI.62.3.1026-1031.1994

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Periodontitis is a common infectious disease in which the attachment tissues of the teeth and their alveolar bone housing are destroyed, resulting in tooth loss. The gram-negative anaerobic microorganism Porphyromonas gingivalis has been closely linked to severe forms of the disease. We show for the first time that immunization of the primate Macaca fascicularis with killed P. gingivalis in Syntex Adjuvant Formulation-M inhibits progression of periodontal tissue destruction.

引用

页码：1026 / 1031

页数：6

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