PEPTIDE NUCLEIC-ACID (PNA) WITH A CHIRAL BACKBONE BASED ON ALANINE

被引：71
作者：
DUEHOLM, KL
PETERSEN, KH
JENSEN, DK
EGHOLM, M
NIELSEN, PE
BUCHARDT, O
机构：
[1] UNIV COPENHAGEN,HC ORSTED INST,MED BIOTECHNOL RES CTR,DK-2100 COPENHAGEN O,DENMARK
[2] UNIV COPENHAGEN,PANUM INST,DEPT BIOCHEM B,MED BIOTECHNOL RES CTR,DK-2200 COPENHAGEN N,DENMARK
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 08期
关键词：
D O I：
10.1016/S0960-894X(01)80684-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A synthesis of N-(2-Boc-aminoethyl)-N-(thymin-1-ylacetyl)aline (5) is presented. It is demonstrated that chiral integrity can be preserved. PNA (Peptide Nucleic Acid) containing the D-form of 5 hybridizes to complementary DNA with higher affinity than PNA containing the L-form of 5.
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页码：1077 / 1080
页数：4
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