ELEVATION OF THE NEUROTOXIN QUINOLINIC ACID OCCURS FOLLOWING SPINAL-CORD TRAUMA

被引：59

作者：

POPOVICH, PG ^{[1
]}

REINHARD, JF ^{[1
]}

FLANAGAN, EM ^{[1
]}

STOKES, BT ^{[1
]}

机构：

[1] WELLCOME RES LABS,DIV PHARMACOL,RES TRIANGLE PK,NC 27709

来源：

BRAIN RESEARCH | 1994年 / 633卷 / 1-2期

关键词：

QUINOLINIC ACID; SPINAL CORD INJURY; INFLAMMATION; MACROPHAGE; MICROGLIA; BLOOD-BRAIN BARRIER;

D O I：

10.1016/0006-8993(94)91560-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Excitatory amino acid neurotoxicity and the inflammatory response are suspected as mediators of some of the pathological sequelae occurring as a result of spinal cord injury. Here we report temporal and regional increases of the NMDA receptor agonist, quinolinic acid (QUIN), in an experimental model of spinal contusion injury. These changes occurred at a time when the blood-brain barrier is known to be dysfunctional and the activation state and density of microglia and macrophages are increased. Thus, alterations in tissue QUIN levels may occur as a result of secondary activation of CNS inflammatory cells or from peripherally derived sources across a damaged blood-brain barrier.

引用

页码：348 / 352

页数：5

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