FOLLISTATIN INHIBITS THE MESODERM-INDUCING ACTIVITY OF ACTIVIN-A AND THE VEGETALIZING FACTOR FROM CHICKEN-EMBRYO

被引：71
作者：
ASASHIMA, M
NAKANO, H
UCHIYAMA, H
SUGINO, H
NAKAMURA, T
ETO, Y
EJIMA, D
DAVIDS, M
PLESSOW, S
CICHOCKA, I
KINOSHITA, K
机构：
[1] INST PHYS & CHEM RES,FRONTIER RES PROGRAM,WAKO,SAITAMA 35101,JAPAN
[2] AJINOMOTO CO INC,CENT RES LABS,KAWASAKI,KANAGAWA 210,JAPAN
[3] FREE UNIV BERLIN,INST MOLEK BIOL & BIOCHEM,W-1000 BERLIN 33,GERMANY
[4] NIPPON MED COLL,BIOL LAB,NAKAHARA,KAWASAKI 211,JAPAN
来源：
ROUXS ARCHIVES OF DEVELOPMENTAL BIOLOGY | 1991年 / 200卷 / 01期
关键词：
MESODERM INDUCTION; ACTIVIN; VEGETALIZING FACTOR; XENOPUS; FOLLISTATIN; FSH;
D O I：
10.1007/BF02457635
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The induction of mesoderm is an important process in early amphibian development. In recent studies, activin has become an effective candidate for a natural mesoderm-inducing factor. In the present study, we show that follistatin, an activin-binding protein purified from porcine ovary, inhibits the mesoderm-inducing activity of recombinant human activin A (rh activin A), which is identical to the erythroid differentiation factor (EDF). The quantity of follistatin required for effective suppression of activin was more than three-fold that of activin (w:w). Follistatin also inhibited the mesoderm-inducing activity of the vegetalizing factor purified from chick embryos, suggesting that the vegetalizing factor is closely related to activin.
引用
收藏
页码：4 / 7
页数：4
相关论文
共 35 条
[1]   THE VEGETALIZING FACTOR BELONGS TO A FAMILY OF MESODERM-INDUCING PROTEINS RELATED TO ERYTHROID-DIFFERENTIATION FACTOR [J].
ASASHIMA, M ;
NAKANO, H ;
UCHIYAMA, H ;
DAVIDS, M ;
PLESSOW, S ;
LOPPNOWBLINDE, B ;
HOPPE, P ;
DAU, H ;
TIEDEMANN, H .
NATURWISSENSCHAFTEN, 1990, 77 (08) :389-391
[2]   MESODERMAL INDUCTION IN EARLY AMPHIBIAN EMBRYOS BY ACTIVIN-A (ERYTHROID-DIFFERENTIATION FACTOR) [J].
ASASHIMA, M ;
NAKANO, H ;
SHIMADA, K ;
KINOSHITA, K ;
ISHII, K ;
SHIBAI, H ;
UENO, N .
ROUXS ARCHIVES OF DEVELOPMENTAL BIOLOGY, 1990, 198 (06) :330-335
[3]  
ASASHIMA M, 1975, ROUX ARCH DEV BIOL, V177, P301, DOI 10.1007/BF00848181
[4]  
ASASHIMA M, 1989, CELL DIFFER DEV S53, V27
[5]   INHIBIN, ACTIVIN, AND FOLLISTATIN - REGULATION OF FOLLICLE-STIMULATING-HORMONE MESSENGER-RIBONUCLEIC-ACID LEVELS [J].
CARROLL, RS ;
CORRIGAN, AZ ;
GHARIB, SD ;
VALE, W ;
CHIN, WW .
MOLECULAR ENDOCRINOLOGY, 1989, 3 (12) :1969-1976
[6]   STRUCTURAL CHARACTERIZATION OF FOLLISTATIN - A NOVEL FOLLICLE-STIMULATING-HORMONE RELEASE-INHIBITING POLYPEPTIDE FROM THE GONAD [J].
ESCH, FS ;
SHIMASAKI, S ;
MERCADO, M ;
COOKSEY, K ;
LING, N ;
YING, S ;
UENO, N ;
GUILLEMIN, R .
MOLECULAR ENDOCRINOLOGY, 1987, 1 (11) :849-855
[7]   PURIFICATION AND CHARACTERIZATION OF ERYTHROID-DIFFERENTIATION FACTOR (EDF) ISOLATED FROM HUMAN-LEUKEMIA CELL-LINE THP-1 [J].
ETO, Y ;
TSUJI, T ;
TAKEZAWA, M ;
TAKANO, S ;
YOKOGAWA, Y ;
SHIBAI, H .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 142 (03) :1095-1103
[8]   A VEGETALIZING INDUCING FACTOR - ISOLATION AND CHEMICAL-PROPERTIES [J].
GEITHE, HP ;
ASASHIMA, M ;
ASAHI, K ;
BORN, J ;
TIEDEMANN, H ;
TIEDEMANN, H .
BIOCHIMICA ET BIOPHYSICA ACTA, 1981, 676 (03) :350-356
[9]  
GREEN JBA, 1990, DEVELOPMENT, V108, P173
[10]   A MESODERM-INDUCING FACTOR FROM A XENOPUS-LAEVIS CELL-LINE - CHEMICAL-PROPERTIES AND RELATION TO THE VEGETALIZING FACTOR FROM CHICKEN EMBRYOS [J].
GRUNZ, H ;
BORN, J ;
DAVIDS, M ;
HOPPE, P ;
LOPPNOWBLINDE, B ;
TACKE, L ;
TIEDEMANN, H ;
TIEDEMANN, H .
ROUXS ARCHIVES OF DEVELOPMENTAL BIOLOGY, 1989, 198 (01) :8-13
1234