THE EFFECTS OF GESTATION ON CIRCULATING PROGENITOR CELLS

被引：13
作者：
JONES, HM
NATHRATH, M
THOMAS, RM
EDELMAN, P
RODECK, CH
LINCH, DC
机构：
[1] UCL, SCH MED, DEPT HAEMATOL, LONDON WC1E 6HX, ENGLAND
[2] UCL, SCH MED, DEPT OBSTET & GYNAECOL, LONDON, ENGLAND
[3] ROSSLYN CLIN, RICHMOND, SURREY, ENGLAND
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 1994年 / 87卷 / 03期
关键词：
FETAL PROGENITORS; ERYTHROPOIETIC; GROWTH FACTORS;
D O I：
10.1111/j.1365-2141.1994.tb08329.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The frequency of BFU-E in second-trimester fetal blood (484 +/- 104/10(5)) falls progressively during gestation to a value of 69 +/- 41/10(5) in cord bloods of 36 weeks gestation and beyond, but this is still significantly greater than adult blood values of 14 +/- 8 (P < 0.01). BFU-E obtained from unfractionated peripheral blood mononuclear cells from fetuses/neonates less than 36 weeks gestation were more sensitive to erythropoietin than adult BFU-E, but the sensitivity of highly purified BFU-E obtained from second-trimester fetal liver as similar to that in adult cells. Almost maximal growth of BFU-E from purified fetal progenitor cells could be achieved with erythropoietin alone, whereas adult cells required the presence of other factors with 'burst-promoting activity'.
引用
收藏
页码：637 / 639
页数：3
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