PRENATAL AND PERINATAL LOW-LEVEL LEAD-EXPOSURE ALTERS BRAIN-STEM AUDITORY-EVOKED RESPONSES IN INFANTS

Wave III latency and the III-V interpeak interval of brainstem auditory evoked responses in infants in the first weeks of life decreased and increased, respectively, in association with mid-pregnancy maternal blood lead levels (2.5-35 mu g/dl) in a group of 30 prospectively followed healthy pregnancies and deliveries. The rapid myelination of brainstem auditory pathways of occurring around mid-pregnancy and the lengthening oi the III- V interpeak interval with increased mid-pregnancy maternal lead suggest that brain structures involved in spatial localization of sound may be compromised by prenatal lead exposure. The data also indicate that maternal blood lead measurements during pregnancy provide an adequate surrogate index of fetal exposure. (C) 1994 Intox Press.