DIURNAL-VARIATION AND BINDING CHARACTERISTICS OF MELATONIN IN THE MOUSE-BRAIN AND GASTROINTESTINAL TISSUES

被引:54
作者
BUBENIK, GA
NILES, LP
PANG, SF
PENTNEY, PJ
机构
[1] MCMASTER UNIV,DEPT BIOMED SCI,HAMILTON L8N 3Z5,ONTARIO,CANADA
[2] UNIV HONG KONG,FAC MED,DEPT PHYSIOL,HONG KONG,HONG KONG
来源
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1993年 / 104卷 / 02期
关键词
D O I
10.1016/0742-8413(93)90027-I
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
1. Compared to night time values, levels of melatonin (M), determined by specific RIA, were lower in the brain and the duodenum-jejunum segment of mice sacrificed in mid-photophase. In other parts of the gut no significant diurnal difference was observed. 2. Highest daytime levels were detected in the stomach (569 pg/ml), lowest in the brain (62 pg/ml). 3. Preliminary studies indicate the presence of specific binding Sites for [I-125]iodomelatonin in the colon, ileum, jejunum, stomach and brain. These sites, which exhibit an affinity of about 1 nM, may be involved in mediating the gastrointestinal and central effects of melatonin in this species.
引用
收藏
页码:221 / 224
页数:4
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