LIPOPOLYSACCHARIDE INDUCES PROSTAGLANDIN-H SYNTHASE-2 IN ALVEOLAR MACROPHAGES

被引：136

作者：

OSULLIVAN, MG ^{[1
]}

HUGGINS, EM ^{[1
]}

MEADE, EA ^{[1
]}

DEWITT, DL ^{[1
]}

MCCALL, CE ^{[1
]}

机构：

[1] MICHIGAN STATE UNIV,DEPT BIOCHEM,E LANSING,MI 48824

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91313-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prostaglandin H synthase is a key enzyme in the formation of prostaglandins and thromboxane from arachidonic acid. The recent cloning of a second prostaglandin H synthase gene, prostaglandin H synthase-2, which is distinct from the classic prostaglandin H synthase-1 gene, may dramatically alter our concept of how cells regulate prostanoid formation. We have recently shown that the enhanced production of prostanoids by lipopolysaccharide-primed alveolar macrophages involves the induction of a novel prostaglandin H synthase (J. Biol. Chem., (1992), 267, 14547-14550). We report here that the novel PGH synthase induced by lipopolysaccharide in alveolar macrophages is prostaglandin H synthase-2. © 1992.

引用

页码：1123 / 1127

页数：5

共 15 条

[1] BACTERIAL LIPOPOLYSACCHARIDES PRIME MACROPHAGES FOR ENHANCED RELEASE OF ARACHIDONIC-ACID METABOLITES [J].