STUDIES ON INDONESIAN MEDICINAL-PLANTS .3. PHENYLACETIC ACID-DERIVATIVES AND A THIOAMIDE GLYCOSIDE FROM ENTADA-PHASEOLOIDES

被引：27
|
作者：
DAI, JR
KARDONO, LBS
TSAURI, S
PADMAWINATA, K
PEZZUTO, JM
KINGHORN, AD
机构：
[1] UNIV ILLINOIS, COLL PHARM, PROGRAM COLLABORAT RES PHARMACEUT SCI, CHICAGO, IL 60612 USA
[2] INDONESIAN INST SCI, RES & DEV CTR APPL CHEM, BANDUNG, INDONESIA
[3] BANDUNG INST TECHNOL, DEPT PHARM, BANDUNG, INDONESIA
[4] UNIV ILLINOIS, COLL PHARM, DEPT MED CHEM & PHARMACOGNOSY, CHICAGO, IL 60612 USA
来源：
PHYTOCHEMISTRY | 1991年 / 30卷 / 11期
关键词：
ENTADA-PHASEOLOIDES; LEGUMINOSAE; SEEDS; 2-HYDROXY-5-BUTOXYPHENYLACETIC ACID; 2-BETA-D-GLUCOPYRANOSYLOXY-5-BUTOXYPHENYLACETIC ACID; 2,5-DIHYDROXYPHENYLACETIC ACID METHYL ESTER; ENTADAMIDE-A-BETA-D-GLUCOPYRANOSIDE; CYTOTOXICITY ASSESSMENT;
D O I：
10.1016/0031-9422(91)80102-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Three new compounds, 2-hydroxy-5-butoxyphenylacetic acid, 2-beta-D-glucopyranosyloxy-5-butoxyphenyl-acetic acid, and entadamide A-beta-D-glucopyranoside, in addition to the new natural product 2,5-dihydroxyphenylacetic acid methyl ester, have been isolated and characterized from seeds of Entada phaseoloides collected in Indonesia. None of these compounds was found to demonstrate significant cytotoxicity for cultured human cancer cells, but 2-hydroxy-5-butoxyphenylacetic acid and 2,5-dihydroxyphenylacetic acid methyl ester gave ED50 values of 1.0 and 1.7-mu-g ml-1, respectively, with cultured P-388 cells.
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页码：3749 / 3752
页数：4
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